Semester 7
BP 704T: NOVEL DRUG DELIVERY SYSTEMS (Theory)
Scope: This subject is designed to impart basic knowledge in the area of novel drug delivery systems.
Objectives: Upon completion of the course student shall be able
1. To understand various approaches for the development of novel drug delivery systems.
2. To understand the criteria for the selection of drugs and polymers for the development of
3. Novel drug delivery systems, their formulation and evaluation
Course content:
Unit-I
Controlled drug delivery systems: Introduction, terminology/definitions and rationale, advantages, disadvantages, selection of drug candidates. Approaches to design controlled release formulations based on diffusion, dissolution and ion exchange principles. Physicochemical and biological properties of drugs relevant to controlled release formulations
Polymers: Introduction, classification, properties, advantages and application of polymers in the formulation of controlled release drug delivery systems.
Unit-II
Microencapsulation: Definition, advantages and disadvantages, microspheres/microcapsules, microparticles, methods of microencapsulation, applications
Mucosal Drug Delivery System: Introduction, Principles of bio adhesion mucoadhesion, concepts, advantages and disadvantages, transmucosal permeability and formulation considerations of buccal delivery systems
Implantable Drug Delivery Systems: Introduction, advantages and Disadvantages, the concept of implants and osmotic pump
Unit-III
Transdermal Drug Delivery Systems: Introduction, Permeation through the skin, factors affecting permeation, permeation enhancers, basic components of TDDS, formulation approaches
Gastroretentive drug delivery systems: Introduction, advantages, disadvantages, approaches for GRDDS – Floating, high-density systems, inflatable and gastroadhesive systems and their applications
Nasopulmonary drug delivery system: Introduction to Nasal and Pulmonary routes of drug delivery, Formulation of Inhalers (dry powder and metered dose), nasal sprays, nebulizers
Unit-IV
Targeted drug Delivery: Concepts and approaches advantages and disadvantages, introduction to liposomes, niosomes, nanoparticles, monoclonal antibodies and their applications
Unit-V
Ocular Drug Delivery Systems: Introduction, intraocular barriers and methods to overcome –Preliminary study, ocular formulations and concerts
Intrauterine Drug Delivery Systems: Introduction, advantages and disadvantages, development of intrauterine devices (IUDs) and applications
Recommended Books: (Latest Editions)
1. Y W. Chien, Novel Drug Delivery Systems, 2nd edition, revised and expanded, Marcel Dekker, Inc., New York, 1992.
2. Robinson, J. R., Lee V. H. L, Controlled Drug Delivery Systems, Marcel Dekker, Inc., New York, 1992.
3. Encyclopedia of Controlled Delivery. Edith Mathiowitz, Published by Wiley Interscience Publication, John Wiley and Sons, Inc, New York. Chichester/Weinheim
4. N.K. Jain, Controlled and Novel Drug Delivery, CBS Publishers & Distributors, New Delhi, First edition 1997 (reprint in 2001).
5. S.P. Vyas and R.K. Khar, Controlled Drug Delivery -concepts and advances, Vallabh Prakashan, New Delhi, First edition 2002.
Journals
1. Indian Journal of Pharmaceutical Sciences (IPA)
2. Indian Drugs (IDMA)
3. Journal of Controlled Release (Elsevier Sciences)
4. Drug Development and Industrial Pharmacy (Marcel & Decker)
5. International Journal of Pharmaceutics (Elsevier Sciences)
Please do not enter any spam link in the comment box.