Pharmaceutical Organic Chemistry III | Best B pharmacy Sem 4 free notes | Pharmacy notes pdf semester wise

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 Semester 4

BP 401 T.  Pharmaceutical Organic Chemistry III  (Theory)

Note: To emphasize definitions, types, mechanisms, examples, uses/applications

UNIT-I

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Stereo isomerism

Optical isomerism – 

Optical activity, enantiomerism, diastereoisomerism, meso compounds

Elements of symmetry, chiral and achiral molecules

DL system of nomenclature of optical isomers, sequence rules, RS system of nomenclature of optical isomers

Reactions of chiral molecules

Racemic modification and resolution of a racemic mixture. 

Asymmetric synthesis: partial and absolute

UNIT-II

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Geometrical isomerism

Nomenclature of geometrical isomers (Cis Trans, EZ, Syn Anti systems)

Methods of determination of the configuration of geometrical isomers.

Conformational isomerism in Ethane, n-Butane, and Cyclohexane. 

Stereo isomerism in biphenyl compounds (Atropisomerism) and conditions for optical

activity. 

Stereospecific and stereoselective reactions

UNIT-III 

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Heterocyclic compounds:

Nomenclature and classification

Synthesis, reactions, and medicinal uses of the following compounds/derivatives

Pyrrole, Furan, and Thiophene

Relative aromaticity and reactivity of Pyrrole, Furan, and Thiophene

UNIT-IV

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Synthesis, reactions, and medicinal uses of the following compounds/derivatives

 Pyrazole, Imidazole, Oxazole, and Thiazole.

Pyridine, Quinoline, Isoquinoline, Acridine and Indole. Basicity of pyridine

Synthesis and medicinal uses of Pyrimidine, Purine, azepines, and their derivatives

UNIT-V

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Reactions of synthetic importance

Metal hydride reduction (NaBH4 and LiAlH4), Clemmensen reduction, Birch reduction, Wolff Kishner reduction.

Oppenauer-oxidation and Dakin reaction.

Beckmann's rearrangement and Schmidt's rearrangement.

Claisen-Schmidt condensation

Recommended Books (Latest Editions)

1. Organic chemistry by I.L. Finar, Volume-I & II. 2. A textbook of organic chemistry – Arun Bahl, B.S. Bahl.

2. 3. Heterocyclic Chemistry by Raj K. Bansal

3. 4. Organic Chemistry by Morrison and Boyd

4. 5. Heterocyclic Chemistry by T.L. Gilchrist