Pharmaceutical Inorganic Chemistry | B pharmacy Semester 1 free notes

  Handwritten Notes

Semester I

BP104T. PHARMACEUTICAL INORGANIC CHEMISTRY (Theory)

UNIT I

•     Impurities in pharmaceutical substances:   History  of   Pharmacopoeia, Sources and types  of   impurities, the principle  involved in   the  limit  test for Chloride, Sulphate, hon,  Arsenic,  Lead and Heavy metals, modified limit test for Chloride and Sulphate

General   methods  of  preparation,  assay  for  the  compounds   superscripted with  asterisk  (*), properties and medicinal uses of inorganic compounds belonging to the following classes

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UNIT II

•     Acids,  Bases and  Buffers: Buffer equations and buffer capacity in general, buffers in pharmaceutical systems, preparation, stability, buffered isotonic solutions, measurements of tonicity,  calculations and methods of adjusting isotonicity.

•    Major extra and intracellular electrolytes: Functions of major physiological ions,  Electrolytes used in the replacement therapy:  Sodium chloride*, Potassium chloride, Calcium gluconate* and Oral Rehydration  Salt (ORS), Physiological acid-base balance.

•     Dental products: Dentifrices,  role of fluoride in the treatment of dental caries,  Desensitizing agents,  Calcium carbonate, Sodium fluoride,  and  Zinc eugenol cement.

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UNIT III

•     Gastrointestinal agents

Acidifiers: Ammonium chloride* and  Dil. HCl

Antacid:   Ideal properties of  antacids, combinations of antacids, Sodium

Bicarbonate*,  Aluminum  hydroxide gel, Magnesium  hydroxide mixture

Cathartics:   Magnesium sulphate, Sodium  orthophosphate,  Kaolin and Bentonite

Antimicrobials: Mechanism, classification, Potassium permanganate,  Boric acid, Hydrogen peroxide*, Chlorinated lime*, Iodine and its preparations

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UNIT IV

•     Miscellaneous compounds

Expectorants:  Potassium iodide, Ammonium chloride*. 

Emetics: Copper sulphate*, Sodium potassium tartrate

Haematinics:  Ferrous sulphate*, Ferrous gluconate

Poison and Antidote: Sodium thiosulphate*, Activated charcoal, Sodium nitrite333

Astringents: Zinc Sulphate, Potash Alum

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UNIT V

•     Radiopharmaceuticals:  Radioactivity,  Measurement of radioactivity, Properties of radiations,  Half-life,  radioisotopes and study of radioisotopes - Sodium iodide  I-131, Storage conditions, precautions & pharmaceutical application of radioactive substances.

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Recommended  Books (Latest Editions)

1.       A.H. Beckett & J.B. Stenlake's, Practical Pharmaceutical Chemistry Vol I & H, Stahlone Press of University of London, 4" edition.

2.       A.I. Vogel, Text Book of Quantitative Inorganic analysis

3.       P. Gundu  Rao, Inorganic Pharmaceutical Chemistry,  3"  Edition

4.       M.L Schroff, Inorganic Pharmaceutical Chemistry

5.       Bentley and Driver's Textbook of Pharmaceutical Chemistry

6.       Anand & Chatwal,  Inorganic Pharmaceutical Chemistry

7.       Indian Pharmacopoeia